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Effect of Fibroblast Growth Factor-2 and Serum on Canine Mesenchymal Stem Cell Chondrogenesis.

Authors
  • Endo, Kentaro1
  • Fujita, Naoki1
  • Nakagawa, Takayuki1
  • Nishimura, Ryohei1
  • 1 Laboratory of Veterinary Surgery, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan. , (Japan)
Type
Published Article
Journal
Tissue Engineering Part A
Publisher
Mary Ann Liebert
Publication Date
Jun 01, 2019
Volume
25
Issue
11-12
Pages
901–910
Identifiers
DOI: 10.1089/ten.TEA.2018.0177
PMID: 30319056
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Tissue engineering using the chondrogenic potential of mesenchymal stem cells (MSCs) is a promising approach for cartilage regenerative therapy. Although dogs are widely used as an animal model for cartilage regeneration, chondrogenic differentiation of canine MSCs is still challenging. In this study, we aimed at establishing the optimal conditions for canine MSC chondrogenesis. Our results demonstrated that preconditioning with fibroblast growth factor-2 and serum-free induction medium enabled robust chondrogenesis of canine MSCs. These findings will allow effective generation of cartilage tissue from canine MSCs and advance research of cartilage regeneration in both dogs and humans.

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