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The effect of the expression of angiotensin II on extracellular matrix metalloproteinase inducer (EMMPRIN) in macrophages is mediated via the AT1/COX-2/PGE2 pathway.

Authors
Type
Published Article
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Publication Date
Volume
59
Issue
12
Pages
1033–1040
Identifiers
DOI: 10.1007/s00011-010-0223-3
PMID: 20563831
Source
Medline
License
Unknown

Abstract

Ang II can up-regulate EMMPRIN expression in THP-1 macrophages via the AT(1)/COX-2/PGE(2) signal transduction pathway, and the effect can be inhibited by losartan and NS-398.

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