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Effect of eurycomanone on cytochrome P450 isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 in vitro

Authors
  • Pan, Yan1
  • Tiong, Kai Hung1
  • Abd-Rashid, Badrul Amini2
  • Ismail, Zakiah2
  • Ismail, Rusli3
  • Mak, Joon Wah1
  • Ong, Chin Eng4
  • 1 International Medical University, School of Medical Sciences, 126 Jalan 19/155B, Bukit Jalil, Kuala Lumpur, 57000, Malaysia , Kuala Lumpur (Malaysia)
  • 2 Institute for Medical Research, Herbal Medicine Research Unit, Division of Biochemistry, Jalan Pahang, Kuala Lumpur, 50588, Malaysia , Kuala Lumpur (Malaysia)
  • 3 Universiti Sains Malaysia, Pharmacogenetics Research Group, Institute for Research in Molecular Medicine, Kubang Kerian, Kelantan, 16150, Malaysia , Kubang Kerian (Malaysia)
  • 4 Monash University Sunway Campus, Jeffrey Cheah School of Medicine and Health Sciences, Jalan Lagoon Selatan, Bandar Sunway, Selangor, 46150, Malaysia , Bandar Sunway (Malaysia)
Type
Published Article
Journal
Journal of Natural Medicines
Publisher
Springer Japan
Publication Date
Jul 24, 2013
Volume
68
Issue
2
Pages
402–406
Identifiers
DOI: 10.1007/s11418-013-0794-8
Source
Springer Nature
Keywords
License
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Abstract

Eurycomanone, an active constituent isolated from Eurycoma longifolia Jack, was examined for modulatory effects on cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 using in vitro assays. The IC50 value was determined to assess the potencies of modulation for each CYP isoform. Our results indicated that eurycomanone did not potently inhibit any of the CYP isoforms investigated, with IC50 values greater than 250 μg/ml. Hence there appears to be little likelihood of drug–herb interaction between eurycomanone or herbal products with high content of this compound and CYP drug substrates via CYP inhibition.

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