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The effect of erythropoietin on rat rotator cuff repair model: An experimental study.

Authors
  • Oztermeli, Ahmet1
  • Karaca, Sinan1
  • Yucel, Istemi1
  • Midi, Ahmet2
  • Sen, Elif Itir2
  • Ozturk, Burak Yagmur1
  • 1 1 Department of Orthopaedics and Traumatology, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey. , (Turkey)
  • 2 2 Department of Pathology, Bahcesehir University Faculty of Medicine, Istanbul, Turkey. , (Turkey)
Type
Published Article
Journal
Journal of orthopaedic surgery (Hong Kong)
Publication Date
Jan 01, 2019
Volume
27
Issue
2
Identifiers
DOI: 10.1177/2309499019856389
PMID: 31234725
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim of this study was to determine whether erythropoietin (EPO) can enhance rotator cuff healing in rats as measured by histological analysis and biomechanical testing. A total of 72 rats were included in this study. In the control group (n = 24), repair was performed without EPO injection. In the local group (n = 24) EPO was injected in the repair site. In the systemic group (n = 24) EPO was administered as an intraperitoneal injection every day for 10 days after repair. Rats were euthanized on day 10 (n = 12 from each group) and day 28 (n = 12 from each group). Histopathological (n = 6) and biomechanical examinations (n = 6) were done. Biomechanical results reveal that the maximum load to failure values of the early control group were statistically lower than those of the early systemic group (p = 0.006). Comparing the the total Bonar values histopathologically reveal that the early systemic group was statistically higher than those of the early local group (p = 0.043). The late control group was statistically higher than those of the late local group (p = 0.003) and the late systemic group (p = 0.034). The late systemic group was statistically higher than those of the late local group (p = 0.003). EPO application had a positive effect biomechanically in the early euthanized group and histopathologically in the late euthanized group.

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