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Effect of epidermal growth factor on ornithine decarboxylase activity and urea synthesis in isolated rat hepatocytes.

Authors
  • Soler, C
  • Poveda, B
  • Soley, M
  • Pastor-Anglada, M
Type
Published Article
Journal
Cellular and molecular biology
Publication Date
May 01, 1992
Volume
38
Issue
3
Pages
281–288
Identifiers
PMID: 1611658
Source
Medline
License
Unknown

Abstract

Ornithine decarboxylase (ODC) activity is induced by protein-synthesis independent mechanisms in freshly isolated rat hepatocytes, incubated either without or with a mixture of amino acids in the incubation medium. Urea synthesis rates were two- to three-fold higher in those hepatocytes incubated in the presence of amino acids that in those lacking amino acids in the medium. Epidermal growth factor (EGF) delayed ODC induction, but only in the presence of amino acids. EGF significantly decreased ureagenesis when hepatocytes were incubated in the presence of amino acids and only endogenous substrates were available. No evidence of any link between ODC induction and urea synthesis was found.

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