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The effect of drug packaging on patients' compliance with treatment for Plasmodium vivax malaria in China.

Authors
  • Qingjun, L
  • Jihui, D
  • Laiyi, T
  • Xiangjun, Z
  • Jun, L
  • Hay, A
  • Shires, S
  • Navaratnam, V
Type
Published Article
Journal
Bulletin of the World Health Organization
Publisher
WHO Press
Publication Date
Jan 01, 1998
Volume
76 Suppl 1
Pages
21–27
Identifiers
PMID: 9763719
Source
Medline
License
Unknown

Abstract

A study conducted in 1994 showed that the use of blister packs containing antimalarial drugs significantly increased patients' compliance, compared with traditional means of dispensing drugs in a paper envelope. The present study assessed patients' compliance and compared the difference between 3-day chloroquine and 8-day primaquine courses of treatment for vivax malaria. The level of real compliance was determined by making the drugs with phenobarbital, and measuring its level in the blood following treatment. The results show that blister packaging significantly improved patients' compliance (p < 0.001) over traditional means of dispensing antimalarial drugs; there was no difference in treatment compliance between 3-day and 8-day courses when the drugs were in blister packs. However, with ordinary packaging the treatment compliance rate for an 8-day course was significantly less than for a 3-day course (P < 0.05).

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