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Effect of dose on the intravenous pharmacokinetics of tolfenamic acid in goats.

Authors
  • Tekeli, Ibrahim Ozan1
  • Turk, Erdinc1
  • Durna Corum, Duygu2
  • Corum, Orhan2
  • Kirgiz, Fatma Ceren1
  • Uney, Kamil3
  • 1 Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkey. , (Turkey)
  • 2 Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Kastamonu, Kastamonu, Turkey. , (Turkey)
  • 3 Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey. , (Turkey)
Type
Published Article
Journal
Journal of veterinary pharmacology and therapeutics
Publication Date
Sep 01, 2020
Volume
43
Issue
5
Pages
435–439
Identifiers
DOI: 10.1111/jvp.12898
PMID: 32743801
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The objective of this study was to determine the pharmacokinetics of tolfenamic acid (TA) following intravenous (IV) administration at doses of 2 and 4 mg/kg in goats. In this study, six healthy goats were used. TA was administered intravenously to each goat at 2 and 4 mg/kg doses in a cross-over pharmacokinetic design with a 15-day washout period. Plasma concentrations of TA were analyzed using the high performance liquid chromatography with ultraviolet detector, and pharmacokinetic parameters were assigned by noncompartmental analysis. Following IV administration at dose of 2 mg/kg, area under the concentration-time curve (AUC0-∞ ), elimination half-life (t1/2ʎz ), total clearance (ClT ) and volume of distribution at steady state (Vdss ) were 6.64 ± 0.81 hr* µg/ml, 1.57 ± 0.14 hr, 0.30 ± 0.04 L h-1 kg-1 and 0.40 ± 0.05 L/kg, respectively. After the administration of TA at a dose of 4 mg/kg showed prolonged t1/2ʎz , increased dose-normalized AUC0-∞ , and decreased ClT . In goats, TA at 4 mg/kg dose can be administered wider dose intervals compared to the 2 mg/kg dose. However, further studies are needed to determine the effect of different doses on the clinical efficacy of TA in goats. © 2020 John Wiley & Sons Ltd.

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