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Effect of domperidone on experimentally induced gastric ulcers in rats.

Authors
  • Parmar, N S
  • Tariq, M
  • Ageel, A M
  • Al-Khamis, K I
Type
Published Article
Journal
International journal of tissue reactions
Publication Date
Jan 01, 1986
Volume
8
Issue
1
Pages
67–70
Identifiers
PMID: 3949445
Source
Medline
License
Unknown

Abstract

The effect of domperidone, a peripheral dopamine receptor antagonist, has been studied in the aspirin, phenylbutazone and reserpine induced gastric ulcers in rats. The gastric anti-ulcer activity of domperidone was evident following a single dose as well as a 5-day pretreatment against all the three ulcerogenic drugs. However, the protection in the five-day pretreatment group was greater than in the single dose pretreatment group. It appears that the gastrokinetic properties of domperidone play a significant role in producing this anti-ulcer effect. The study substantiates the results of the clinical observations on the healing of gastric ulcers and provides a rationale for further clinical studies in that direction. The possible mechanisms of action of this agent are discussed.

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