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Effect of divided daily dose prednisone therapy on circulating T cell subsets.

Authors
  • Hepburn, B
  • Slade, J D
Type
Published Article
Journal
The Journal of rheumatology
Publication Date
Feb 01, 1987
Volume
14
Issue
1
Pages
19–22
Identifiers
PMID: 2952795
Source
Medline
License
Unknown

Abstract

Prednisone induced reductions in the circulating human T cell population follow a characteristic time curve which persists even after a single daily dose of oral prednisone has been administered many times. If prednisone doses are administered every 6 h, so that a dose occurs near the point of maximum response from a previous dose (4-6 h), the reduction in size of the circulating T cell population will persist so long as administration of prednisone continues. A chronically depressed ratio of OKT4+ to OKT8+ cells is observed in most patients when as little as 2.5 mg of prednisone is administered every 6 h.

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