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[The effect of dilantin on the neuronal reactions of the sensorimotor cortex and hippocampus during learning].

Authors
  • Shul'gina, G I
Type
Published Article
Journal
Zhurnal vyssheĭ nervnoĭ deiatelnosti imeni I P Pavlova
Publication Date
Jan 01, 1994
Volume
44
Issue
4-5
Pages
714–720
Identifiers
PMID: 7810213
Source
Medline
License
Unknown

Abstract

After dilantin (D) administration in a dose which reduced posttetanic potentiation (according to the data of literature), probability of movements to light flashes (conditioned signal of a defensive reflex) did not change. Weak but stable disinhibition of motor reactions to flashes was observed when they were presented at the background of continuous light as a conditioned inhibitor. Activation of neurons of the sensorimotor cortex in response to reinforced and non-reinforced light flashes increased under D action (as it had been earlier observed in neurons of the visual cortex), and activatory reactions to pain reinforcement decreased. In hippocampal neurons increase of the rate of impulsation in response to reinforced flashes under the action of D disappeared. On the basis of the data obtained it can be concluded that PTP in the neocortex does not participate in long-term memory storage of the biological significance of activating stimulus.

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