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Effect of diacetyl rhein on the development of experimental osteoarthritis. A biochemical investigation.

Authors
  • Carney, S L
Type
Published Article
Journal
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
Publication Date
Dec 01, 1996
Volume
4
Issue
4
Pages
251–261
Identifiers
PMID: 11048622
Source
Medline
License
Unknown

Abstract

DAR was well tolerated by the experimental animals, but did not produce significant changes in the synthesis or turnover of proteoglycans. The slight reduction in proteoglycan synthesis may prove to be biologically significant after chronic dosing. DAR's effects on the hydroxyproline and glycosaminoglycan content suggest, however, that it must influence the swelling of cartilage and loss of glycosaminoglycan. This indicates that small changes can translate, to significant differences in cartilage composition over an 11-week time period.

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