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Effect of diabetes mellitus on salivary paracetamol elimination.

Authors
  • Adithan, C
  • Danda, D
  • Swaminathan, R P
  • Indhiresan, J
  • Shashindran, C H
  • Bapna, J S
  • Chandrasekar, S
Type
Published Article
Journal
Clinical and experimental pharmacology & physiology
Publication Date
Jun 01, 1988
Volume
15
Issue
6
Pages
465–471
Identifiers
PMID: 3271619
Source
Medline
License
Unknown

Abstract

1. Salivary elimination of paracetamol was studied in nine type I and ten type II diabetics. Ten healthy volunteers served as a control group. 2. A significant increase in the elimination half-life (t1/2) and apparent volume of distribution was observed in type I diabetics compared with controls. Clearance rate (CL) was not significantly altered. 3. In type II diabetics paracetamol elimination t1/2 was significantly increased with a corresponding decrease in CL. Apparent volume of distribution of the drug was not significantly different. 4. Paracetamol elimination t1/2 had significant correlation with fasting blood sugar values.

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