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Effect of diabetes mellitus on salivary paracetamol elimination.

Authors
Type
Published Article
Journal
Clinical and Experimental Pharmacology and Physiology
0305-1870
Publisher
Wiley Blackwell (Blackwell Publishing)
Publication Date
Volume
15
Issue
6
Pages
465–471
Identifiers
PMID: 3271619
Source
Medline

Abstract

1. Salivary elimination of paracetamol was studied in nine type I and ten type II diabetics. Ten healthy volunteers served as a control group. 2. A significant increase in the elimination half-life (t1/2) and apparent volume of distribution was observed in type I diabetics compared with controls. Clearance rate (CL) was not significantly altered. 3. In type II diabetics paracetamol elimination t1/2 was significantly increased with a corresponding decrease in CL. Apparent volume of distribution of the drug was not significantly different. 4. Paracetamol elimination t1/2 had significant correlation with fasting blood sugar values.

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