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The effect of dextran 40 and Dazmegrel on early platelet deposition onto vascular grafts.

Authors
  • Pärsson, H
  • Jönsson, B A
  • Norgren, L
  • Thörne, J
Type
Published Article
Journal
VASA. Zeitschrift für Gefässkrankheiten
Publication Date
Jan 01, 1990
Volume
19
Issue
3
Pages
242–246
Identifiers
PMID: 1700560
Source
Medline
License
Unknown

Abstract

Platelet deposition onto double velour Dacron (n = 14) and double velour Dacron with internal collagen (n = 14) interposition grafts were examined experimentally. The accumulation was assessed by reinfusion of 111In labelled platelets and imaging with a scintillation camera. One group received Dextran-40 intravenously (n = 14) and one group received Dazmegrel (n = 14) intravenously. No graft occlusions were noted. Differences in effects of Dextran-40 and Dazmegrel were not observed. The study indicates a beneficial effect of infused Dextran-40 as well as Dazmegrel. The explanation might be reduced interaction graft wall versus blood-platelets.

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