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Effect of dexamethasone on immunoreactive corticotropin-releasing factor in the rat median eminence and intermediate-posterior pituitary.

Authors
  • Suda, T
  • Tomori, N
  • Tozawa, F
  • Mouri, T
  • Demura, H
  • Shizume, K
Type
Published Article
Journal
Endocrinology
Publication Date
Mar 01, 1984
Volume
114
Issue
3
Pages
851–854
Identifiers
PMID: 6321142
Source
Medline
License
Unknown

Abstract

Immunoreactive ACTH (I-ACTH) concentrations in the anterior pituitary, intermediate-posterior pituitary (IP), and plasma and immunoreactive corticotropin-releasing factor (I-CRF) concentrations in the median eminence and IP were determined in rats receiving dexamethasone for various periods from 16 h to 10 days. Plasma I-ACTH concentrations were decreased 16 h after a single injection of dexamethasone. Anterior pituitary I-ACTH concentrations did not decrease until 4 days after the start of dexamethasone medication. IP I-ACTH concentrations did not change throughout these periods. I-CRF concentrations in median eminence and IP rapidly decreased after dexamethasone administration. These results raise the possibility that the source of I-CRF in the IP is hypothalamic.

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