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Effect of desogestrel-containing oral contraceptives on vascular reactivity and catecholamine levels.

Authors
  • Arangino, S
  • Cagnacci, A
  • Angiolucci, M
  • Longu, G
  • Melis, G B
  • Volpe, A
Type
Published Article
Journal
Contraception
Publisher
Elsevier
Publication Date
Nov 01, 1998
Volume
58
Issue
5
Pages
289–293
Identifiers
PMID: 9883384
Source
Medline
Keywords
License
Unknown

Abstract

The effects on blood pressure of oral contraceptives (OCs) containing desogestrel plus either 20 or 30 mcg of ethinyl estradiol were investigated in 22 women who had been using one of these formulations for 6 months or more and 22 matched controls. There were no significant differences between both groups of cases and controls in blood pressure measured at rest in supine position. However, subtle differences were recorded in vascular reactivity, as evaluated by color Doppler ultrasound investigation. Compared to controls and users of OCs containing 20 mcg of ethinyl estradiol, cases taking OCs consisting of 30 mcg of ethinyl estradiol had a significantly higher pulsatility index in the axillary artery, indicating increased vessel resistance to blood flow. A similar, although not significant, trend was found in the internal carotid artery pulsatility index. On the other hand, catecholamine (dopamine and norepinephrine) levels were reduced by both OCs in a dose-dependent manner. Overall, these findings suggest that third-generation OCs, especially those containing 20 mcg of ethinyl estradiol, exert minimal effects on circulatory parameters. It is hypothesized that the cardiovascular effects of catecholamine reduction are antagonized by other mechanisms, among them the stimulus on the renin-angiotensin system.

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