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Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis

  • Pickich, Matthew B.1
  • Hargrove, Mark W.1
  • Phillips, C. Niles1
  • Healy, James C.1
  • Moore, Angelique N.1
  • Roberts, Michael D.1, 2
  • Martin, Jeffrey S.1, 2, 3
  • 1 Edward Via College of Osteopathic Medicine-Auburn Campus, Department of Cell Biology and Physiology, Auburn, AL, 36832, USA , Auburn (United States)
  • 2 Auburn University, School of Kinesiology, Auburn, AL, 36849, USA , Auburn (United States)
  • 3 Debusk College of Osteopathic Medicine, Department of Basic Medical Sciences, Knoxville, TN, 37932, USA , Knoxville (United States)
Published Article
BMC Research Notes
Springer (Biomed Central Ltd.)
Publication Date
Aug 09, 2019
DOI: 10.1186/s13104-019-4540-5
Springer Nature


ObjectiveWe recently reported that curcumin supplementation in a metabolically (i.e., Western diet [WD]) and chemically (i.e., CCl4) induced female rat model of non-alcoholic steatohepatitis (NASH) was associated with lower liver pathology scores and molecular markers of inflammation. This occurred when curcumin was given during induction of disease (preventative arm; 8-week WD with or without curcumin [8WD + C vs. 8WD]) as well as when given after disease development (treatment arm; 12-week WD with or without curcumin during weeks 9–12 [12WD + C vs. 12WD]). Herein, we sought to extend our findings from that study by determining the effects of curcumin supplementation on cytokine/chemokine expression in serum collected from these same rats.Results24 cytokines/chemokines were assayed. IL-2 (+ 80%) and IL-13 (+ 83%) were greater with curcumin supplementation in the prevention arm. IL-2 (+ 192%), IL-13 (+ 87%), IL-17A (+ 81%) and fractalkine (+ 121%) were higher while RANTES was lower (− 22%) with curcumin supplementation in the treatment arm (p < 0.05 for all). RANTES concentrations also correlated significantly with hepatic pathology scores of inflammation (r = 0.417, p = 0.008). Select serum cytokines/chemokines were affected with curcumin supplementation in this female rat model of NASH. Moreover, curcumin’s effect(s) on RANTES and its association with liver disease pathogenesis and progression may warrant further investigation.

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