Norfloxacin is employed as in veterinary and human medicine against gram-positive and gram-negative bacteria. Due to the ineffective treatment at the wastewater treatment plants it becomes an emergent pollutant. Electro-oxidation appears as an alternative to its effective mineralization. This work compares Norfloxacin electro-oxidation on different anodic materials: two ceramic electrodes (both based on SnO2 + Sb2O3 with and without CuO, named as CuO and BCE, respectively) and a boron doped diamond (BDD). First, the anodes were characterized by cyclic voltammetry, revealing that NOR direct oxidation occurred at 1.30 V vs. Ag/AgCl. The higher the scan rate the higher both the current density and the anodic potential of the peak. This behavior was analyzed using the Randles-Sevcik equation to calculate the Norfloxacin diffusion coefficient in aqueous media, giving a value of D = 7.80 × 10-6 cm2 s-1 at 25 °C), which is close to the predicted value obtained using the Wilke-Chang correlation. The electrolysis experiments showed that both NOR and TOC decay increased with the applied current density, presenting a pseudo-first order kinetic. All the anodes tested achieved more than 90% NOR degradation at each current density. The CuO is not a good alternative to BCE because although it acts as a catalyst during the first use, it is lost from the anode surface in the subsequent uses. According to their oxidizing power, the anodes employed are ordered as follows: BDD > BCE > CuO. Copyright © 2020 Elsevier Ltd. All rights reserved.