Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein.

Authors
  • 1
  • 1 Institute of Natural Products for Health Promotion and Department of Preventive Medicine, College of Medicine, Kosin University, Busan, 602-702, Korea. , (North Korea)
Type
Published Article
Journal
Journal of Natural Products
1520-6025
Publisher
American Chemical Society
Publication Date
Volume
72
Issue
10
Pages
1731–1734
Identifiers
DOI: 10.1021/np800797v
PMID: 19807114
Source
Medline
License
Unknown

Abstract

Fucoidans are sulfated fucosylated polymers from brown algae cell walls. We assessed the inhibitory effects of Costaria costata fucoidan on UVB-induced MMP-1 promoter, mRNA, and protein expression in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP-1 protein expression compared to UVB irradiation alone. Fucoidan significantly reduced MMP-1 mRNA expression and inhibited UVB-induced MMP-1 promoter activity by 37.3%, 53.3%, and 58.5% at 0.01, 0.1, and 1 microg/mL, respectively, compared to UVB irradiation alone. C. costata fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.

Statistics

Seen <100 times