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Effect of copper deficiency on prenatal development and pregnancy outcome.

Authors
Type
Published Article
Journal
The American journal of clinical nutrition
Publication Date
Volume
67
Issue
5 Suppl
Identifiers
PMID: 9587143
Source
Medline
License
Unknown

Abstract

Copper deficiency during embryonic and fetal development can result in numerous gross structural and biochemical abnormalities. Such a deficiency can arise through a variety of mechanisms, including low maternal dietary copper intake, disease-induced or drug-induced changes in maternal and conceptus copper metabolism, or both. These issues are discussed in this article along with the use of in vitro embryo culture models to study the mechanisms underlying copper deficiency-induced teratogenesis. Current data suggest that changes in free radical defense mechanisms, connective tissue metabolism, and energy production can all contribute to the dysmorphogenesis associated with developmental copper deficiency.

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