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Effect of controlled-release delivery on the pharmacokinetics of oxybutynin at different dosages: severity-dependent treatment of the overactive bladder.

Authors
  • Preik, Michael
  • Albrecht, Detlef
  • O'Connell, Martin
  • Hampel, Christian
  • Anderson, Rodney
Type
Published Article
Journal
BJU international
Publication Date
Oct 01, 2004
Volume
94
Issue
6
Pages
821–827
Identifiers
PMID: 15476516
Source
Medline
License
Unknown

Abstract

The pharmacokinetics of OROS-O are proportional to dose, with minimal fluctuations between peak and trough concentrations, as associated with IR-O. In clinical practice OROS-O may thus facilitate the highly effective severity-dependent treatment of UUI with flexible dose adaptations based on the patients' needs.

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