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The effect of contraceptives containing nonoxynol-9 on the genital transmission of simian immunodeficiency virus in rhesus macaques.

Authors
  • Miller, C J1
  • Alexander, N J
  • Gettie, A
  • Hendrickx, A G
  • Marx, P A
  • 1 California Regional Primate Research Center, University of California, Davis 95616.
Type
Published Article
Journal
Fertility and Sterility
Publisher
Elsevier
Publication Date
May 1992
Volume
57
Issue
5
Pages
1126–1128
Identifiers
PMID: 1315297
Source
Medline
License
Unknown

Abstract

The ability of two nonoxynol-9 spermicide preparations to prevent the genital transmission of SIV in rhesus macaques was compared. Administration of one mL of contraceptive foam before the intravaginal inoculation of cell-free SIV prevented the genital transmission of SIV to three of six animals, and using one mL of contraceptive gel prevented the genital transmission of SIV to two of six animals. Thus, both contraceptive foams and gels containing nonoxynol-9 provided protection against the genital transmission of SIV.

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