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The effect of continuous vasopressin infusion on splanchnic blood flow, liver function, and portal and central venous pressures in patients with cirrhosis.

Authors
  • Ranek, L
  • Vilstrup, H
  • Iversen, J
  • Petersen, P
  • Milandri, M
Type
Published Article
Journal
Scandinavian journal of clinical and laboratory investigation
Publication Date
May 01, 1984
Volume
44
Issue
3
Pages
251–256
Identifiers
PMID: 6610200
Source
Medline
License
Unknown

Abstract

Continuous vasopressin infusion has been shown to control bleeding from oesophageal varices in patients with cirrhosis of the liver. The mortality, however, has not been changed. To investigate whether reduction of portal blood flow over a period of hours deteriorates the liver function, we measured the splanchnic blood flow and galactose and oxygen consumption in five cirrhotic patients during liver vein catheterization. Vasopressin was given as a continuous infusion of 0.2 units per min for three h. The splanchnic blood flow was reduced to 70% of control values and remained so throughout the infusion. After three h no impairment of the liver function was found. The wedged hepatic pressure (portal pressure) rose slightly, probably due to the increase of the central venous pressure reflecting impaired cardiac function. The reported beneficial effect of vasopressin on varix bleeding probably depends on the reduced portal flow per se.

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