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Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages.

Authors
  • Popēna, Ineta1
  • Ābols, Artūrs2
  • Saulīte, Līga1
  • Pleiko, Kārlis1
  • Zandberga, Elīna2
  • Jēkabsons, Kaspars1
  • Endzeliņš, Edgars2
  • Llorente, Alicia3
  • Linē, Aija2
  • Riekstiņa, Una4
  • 1 Faculty of Medicine, University of Latvia, Raina blvd. 19, Riga, LV-1568, Latvia. , (Latvia)
  • 2 Latvian Biomedical Research and Study Centre, Ratsupites iela 1, Riga, LV-1067, Latvia. , (Latvia)
  • 3 Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, 0379, Oslo, Norway. , (Norway)
  • 4 Faculty of Medicine, University of Latvia, Raina blvd. 19, Riga, LV-1568, Latvia. [email protected] , (Latvia)
Type
Published Article
Journal
Cell communication and signaling : CCS
Publication Date
Apr 24, 2018
Volume
16
Issue
1
Pages
17–17
Identifiers
DOI: 10.1186/s12964-018-0229-y
PMID: 29690889
Source
Medline
Keywords
License
Unknown

Abstract

Our results suggest that CRC cell line-derived EVs are internalized and reprogram the immunophenotype and secretory profile in monocytes and inactive macrophages inducing mixed M1 and M2 cytokine response. Although CRC EVs decreased HLA-DR expression in M1, M2 polarized macrophages, their effect on the secretory profile of M1 and M2 polarized macrophages was negligible.

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