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Effect of chronic dietary ethanol in the promotion of N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats.

Authors
  • Tsutsumi, Mikihiro
  • George, Joseph
  • Ishizawa, Kiyohiro
  • Fukumura, Atushi
  • Takase, Shujiro
Type
Published Article
Journal
Journal of gastroenterology and hepatology
Publication Date
May 01, 2006
Volume
21
Issue
5
Pages
805–813
Identifiers
PMID: 16704527
Source
Medline
License
Unknown

Abstract

The increased expression of CYP2E1 induced by chronic ethanol consumption promotes the development of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis. However, the molecular mechanism of the increased production of esophageal tumors during alternative administration of N-nitrosomethylbenzylamine and ethanol is not clear.

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