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The effect of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming test.

Authors
  • Maj, J
  • Rogóz, Z
  • Skuza, G
  • Sowińska, H
Type
Published Article
Journal
Polish journal of pharmacology and pharmacy
Publication Date
Jan 01, 1992
Volume
44
Issue
4
Pages
337–346
Identifiers
PMID: 1363131
Source
Medline
License
Unknown

Abstract

The present study examined the effects of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming test in rats and mice. Administered in a single dose or three times both examined compounds reduced the immobility time in rats. Active doses used in that test either did not change the locomotor activity or decreased it. A similar effect in both tests was shown by active (R)-enantiomers CGP 40116 and CGP 43487. Reduction of the immobility time induced by CGP 37849 and CGP 39551 in the forced swimming test in rats was antagonized by haloperidol and (+/-)-sulpiride, but not by SCH 23390 or prazosin. CGP 37849, but not CGP 39551, also reduced the immobility time in the forced swimming test in mice. The results obtained indicate that CGP 37849 and CGP 39551 induce an antidepressant-like effect in the forced swimming test, probably via an indirect dopamine activation resulting from blockade of NMDA receptors.

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