Affordable Access

Effect of cell culture conditions on the anticytomegalovirus activity of maribavir.

Authors
  • Chou, Sunwen
  • Van Wechel, Laura C
  • Marousek, Gail I
Type
Published Article
Journal
Antimicrobial agents and chemotherapy
Publication Date
Jul 01, 2006
Volume
50
Issue
7
Pages
2557–2559
Identifiers
PMID: 16801445
Source
Medline
License
Unknown

Abstract

The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors.

Report this publication

Statistics

Seen <100 times