Affordable Access

Effect of the Ca2+ chelators EDTA and EGTA on sinoatrial-node activity and heart irritability.

Authors
  • Solti, F
  • Juhász-Nagy, S
  • Kecskeméti, V
  • Czakó, B
  • Németh, V
  • Kékesi, V
Type
Published Article
Journal
Acta physiologica Academiae Scientiarum Hungaricae
Publication Date
Jan 01, 1982
Volume
60
Issue
3
Pages
155–164
Identifiers
PMID: 6821017
Source
Medline
License
Unknown

Abstract

The effect of the Ca-chelators EDTA and EGTA on sinoatrial activity and heart irritability was studied in dog experiments by perfusing the artery supplying the sinoatrial node. Beside the usual ECG recordings left and right atrial and left and right ventricular epicardial electrograms, His-bundle electrogram and the early activity of the sinoatrial node were recorded. In addition action potentials were recorded from the left auricle and right ventricle of the dog hearts. Local application around the sinoatrial and atrio-ventricular nodes of EDTA and EGTA caused sinus bradycardia and later sinus arrest within 1 min after introduction of the drugs. For substitution of the sinus rhythm junctional (seldom lower atrial) escape rhythm developed. One to two minutes later it was followed by atrial premature beats and even later atrial flutter and fibrillation could be recorded. In one third of the cases atrial fibrillation was followed by secondary ventricular fibrillation. Atrio-ventricular impulse conduction was prolonged in the av node by EDTA and EGTA. Atrial action potentials and the slow (Ca dependent) ventricular action potentials were depressed by EDTA and EGTA.

Report this publication

Statistics

Seen <100 times