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Effect of budesonide on fibroblast-mediated collagen gel contraction and degradation.

Authors
  • Fang, Qiuhong
  • Schulte, Nancy A
  • Kim, Huijung
  • Kobayashi, Tetsu
  • Wang, Xingqi
  • Miller-Larsson, Anna
  • Wieslander, Elisabet
  • Toews, Myron L
  • Liu, Xiangde
  • Rennard, Stephen I
Type
Published Article
Journal
Journal of inflammation research
Publication Date
Jan 01, 2013
Volume
6
Pages
25–33
Identifiers
DOI: 10.2147/JIR.S35136
PMID: 23576875
Source
Medline
Keywords
License
Unknown

Abstract

These findings demonstrate that budesonide directly modulates contraction of collagen gels and can decrease collagen degradation under Inflammatory conditions. The mechanism of this effect is through suppressing gene expression, release, and activation of metalloproteinases. By modulating the release and activity of metalloproteinases, inhaled budesonide may be able to modify airway tissue repair and remodeling.

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