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[The effect of bromocryptin on rotational activity in rats].

Authors
Type
Published Article
Journal
Eksperimental'naia i klinicheskaia farmakologiia
Publication Date
Volume
56
Issue
2
Pages
13–16
Identifiers
PMID: 8348026
Source
Medline
License
Unknown

Abstract

The experiments were made in rats with unilateral lesion to the nigrostriatal tract, which was induced by the highly active dopaminergic neurotoxin 1-methyl-4-phenyl-pyridinium. The rotational activity of rats was evaluated after intragastric and subcutaneous bromocryptine given in a single dose of 10 mg/kg and 25 mg/kg one, two, three and four times. The highest effect of the drug was seen when it was used in the maximum dose of 25 mg/kg, but when the agent is repeatedly given in the above dose, it failed to enhance the rotational activity of rats. The findings may provide evidence for possibilities of increasing the doses of bromocryptine in practical medicine, and for designing the injectable dosage form of the drug.

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