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[The effect of bonnecor on cardiac hemodynamics, blood supply and function in experimental myocardial ischemia].

Authors
  • Chichkanov, G G
  • Tolmacheva, E A
  • Lyskovtsev, V V
  • Grigor'eva, E K
  • Matsievskiĭ, D D
Type
Published Article
Journal
Farmakologiia i toksikologiia
Publication Date
Jan 01, 1990
Volume
53
Issue
3
Pages
38–40
Identifiers
PMID: 2387378
Source
Medline
License
Unknown

Abstract

The effect of a new antiarrhythmic drug bonnecor on the hemodynamics, blood supply and function of the ischemic heart as compared with the famous antiarrhythmic drugs lidocaine and ethacizine was studied in the experiments on anesthetized animals (rats, dogs) under artificial respiration. It was shown that bonnecor administered in a dose of 0.5 mg/kg was able of relieving disturbances of the cardiac hemodynamics and function produced by occlusion of the coronary artery. The drug exerted no significant effect on the blood supply to the focus of acute and chronic myocardial ischemia.

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