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Effect of beta-blocking agents in hyperthyroidism.

Authors
Type
Published Article
Journal
Acta medica Academiae Scientiarum Hungaricae
Publication Date
Volume
36
Issue
4
Pages
375–380
Identifiers
PMID: 45285
Source
Medline

Abstract

Propranolol modifies peripheral thyroxine metabolism, in opposition to the beta blocking agent GYKI 41099 which has no such effect. Both beta-receptor blockers produce a significant fall in the serum cAMP level of hyperthyroid subjects. It is suggested that the beneficial effect of the beta-blocking agents in hyperthyroidism is partly due to their depressive effect on cAMP production. As far as the action of propranolol is concerned, it may well involve an additional effect on T4 metabolism.

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