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Effect of aztreonam on immunohistochemical localizations of cytochrome P-450 (M-1) in male rats.

Authors
  • Sagami, F
  • Tsukidate, K
  • Fukuda, T
  • Hayashi, S
  • Horie, T
Type
Published Article
Journal
Research communications in chemical pathology and pharmacology
Publication Date
Sep 01, 1989
Volume
65
Issue
3
Pages
337–344
Identifiers
PMID: 2813957
Source
Medline
License
Unknown

Abstract

The localization of sex-specific cytochrome P-450, P-450 (M-1), was investigated immunohistochemically in the liver of untreated- and Aztreonam-treated male rats. P-450 (M-1) was uniformly distributed in the liver lobule of untreated rats. By treatment with Aztreonam, P-450 (M-1) was decreased more in the periportal region rather than the pericentral region of the lobule. In addition, oxidation of testosterone and 1 alpha-hydroxycholecalciferol catalyzed by P-450 (M-1) was also decreased by Aztreonam administration.

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