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Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats.

Authors
  • Bhanwra, S
  • Singh, J
  • Khosla, P
Type
Published Article
Journal
Indian journal of physiology and pharmacology
Publication Date
Jan 01, 2000
Volume
44
Issue
1
Pages
64–68
Identifiers
PMID: 10919097
Source
Medline
License
Unknown

Abstract

The effect of aqueous leaf extract of Azadirachta indica (A. indica) was evaluated in paracetamol induced hepatotoxicity in rats. Liver necrosis was produced by administering single dose of paracetamol (2 g/kg, p.o.). The liver damage was evidenced by elevated levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Aqueous A. indica leaf extract (500 mg/kg, p.o.) significantly (P < 0.01) reduced these elevated levels of AST, ALT and gamma-GT. Paracetamol induced liver necrosis was also found to be reduced as observed macroscopically and histologically.

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