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Effect of ascorbic acid administration on B and E apoproteins in rats fed a cholesterol enriched diet.

Authors
  • Santillo, M
  • Santangelo, F
  • Belfiore, A
  • Mastursi, M
  • Mondola, P
Type
Published Article
Journal
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
Publication Date
Mar 01, 1993
Volume
25
Issue
3
Pages
156–159
Identifiers
PMID: 8477953
Source
Medline
License
Unknown

Abstract

The effect of ascorbic acid on cholesterol metabolism is very well documented; it is ascribed to the activation of this vitamin on cholesterol 7 alpha-hydroxylase (EC 1.14) that activates the catabolism of cholesterol. In this paper we have studied the effect of the administration of ascorbic acid on B and E apoproteins of rats fed a diet enriched with 1.5% of cholesterol. The results obtained show that ascorbic acid is able to affect cholesterol metabolism by modifying the serum levels of apo B in total serum and in lipoprotein classes of density less than 1.050 g/ml. Moreover the ascorbic acid treatment reduced the amount of cholesterol and triglycerides in all lipoprotein classes examined. No significant change of total serum apo E was observed following ascorbic acid administration.

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