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The effect of anti-oestrogens on cytokine production in vitro.

Authors
  • Järvinen, L S
  • Pyrhönen, S
  • Kairemo, K J
  • Paavonen, T
Type
Published Article
Journal
Scandinavian journal of immunology
Publication Date
Jul 01, 1996
Volume
44
Issue
1
Pages
15–20
Identifiers
PMID: 8693287
Source
Medline
License
Unknown

Abstract

Oestrogens can regulate immune functions, and due to this females have more effective immune responses than males. Oestrogens and anti-oestrogens enhance T-cell-dependent antibody production of B cells in vitro. The cytokine mediators which are behind oestrogen and anti-oestrogen induced effects are not yet known. The authors studied whether anti-oestrogens (tamoxifen and toremifene) can regulate PMA-induced cytokine production of B-, T- or myeloid cell lines. Anti-oestrogens, tamoxifen and toremifene, stimulated overall cytokine production on a B-cell line (Ball), whereas on a T-cell line (Molt-4) tamoxifen stimulated IL-1 beta, IL-6 and IFN-gamma production and toremifene inhibited it. Anti-oestrogens did not have any significant effect on cytokine production of myeloid cells.

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