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Effect of aminoguanidine on the conjunctival histamine and nitrite levels in experimental conjunctivitis.

Authors
  • Papathanassiou, Miltiadis
  • Giannoulaki, Vasiliki
  • Zampeli, Evangelia
  • Tiligada, Ekaterini
Type
Published Article
Journal
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Publication Date
Apr 01, 2011
Volume
27
Issue
2
Pages
137–142
Identifiers
DOI: 10.1089/jop.2010.0147
PMID: 21500983
Source
Medline
License
Unknown

Abstract

The data suggested that DAO may not be the main route of in situ histamine catabolism in the normal and C48/80-challenged rat conjunctiva, whereas NOS contributes to the phenotypic alterations observed in mast cell-dependent conjunctivitis. Mast cell stabilizing agents and AMG-modulated systems seem to interact through yet undefined mechanisms in the different phases of ocular hypersensitivity reactions.

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