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[Effect of allicin on ethanol-induced hepatotoxicity in mice].

Authors
  • Wang, H
  • Peng, R
  • Kong, R
  • Zeng, H
Type
Published Article
Journal
Wei sheng yan jiu = Journal of hygiene research
Publication Date
Nov 30, 1998
Volume
27
Issue
6
Pages
415–417
Identifiers
PMID: 11939034
Source
Medline
License
Unknown

Abstract

To study the effect of allicin, an effective component of garlic, on ethanol-induced hepatotoxicity in mice. The results showed that allicin (10 mg/kg ig, qd x 10) could reverse the higher activities of serum ALT and glutathione s-transferase (GST) in ethanol-treated mice. Furthermore, allicin could significantly enhance the content of hepatic reduced glutathione (GSH), and the activities of hepatic glutathione peroxidase (GSH-Px), glutathione reductase (GSH-Re) and GST in ethanol-induced hepatotoxicity mice. There were no remarkable changes in the hepatic catalase (Cat) and superoxide dismutase(SOD) activities. These results suggested that allicin have the effective hepato-protection on ethanol-induced hepatotoxicity, which is related to its selective effect on the glutathione-related enzyme system.

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