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Effect of alcohols on filamentation, growth, viability and biofilm development in Candida albicans.

Authors
  • Chauhan, Nitin M1
  • Shinde, Ravikumar B1
  • Karuppayil, S Mohan1
  • 1 DST-FIST and UGC-SAP Sponsored School of Life Sciences, SRTM University, Nanded, M.S, India. , (India)
Type
Published Article
Journal
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
Publication Date
Dec 01, 2013
Volume
44
Issue
4
Pages
1315–1320
Identifiers
DOI: 10.1590/S1517-83822014005000012
PMID: 24688528
Source
Medline
Keywords
License
Unknown

Abstract

In this study we report the potential of alcohols as morphogenetic regulators in Candida albicans. All the alcohols tested influenced various modes of growth like planktonic as well as biofilm forms. Viability was affected at high concentrations. Among the alcohols, the response of C. albicans to amyl alcohol (pentanol) was noteworthy. Amyl alcohol at a concentration 0.5% which was not inhibitory to growth and viability specifically inhibited morphogenetic switching from yeast to hyphal forms. It also inhibited normal biofilm development favoring yeast dominated biofilms. Based on this study we hypothesize that alcohols produced under anaerobic conditions may not favor biofilm development and support dissemination of yeast cells. Since anaerobic conditions are not found to favor production of quorum sensing molecules like farnesol, the alcohols may play a role in morphogenetic regulation.

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