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Effect of Administration of Selenium Nanoparticles Synthesized Using Onion Extract on Biochemical and Inflammatory Parameters in Mice Fed with High-Fructose Diet: In Vivo and In Silico Analysis.

Authors
  • Martínez-Esquivias, Fernando1
  • Perez-Larios, Alejandro2
  • Guzmán-Flores, Juan Manuel3
  • 1 Instituto de Investigación en Biociencias, Centro Universitario de Los Altos, Universidad de Guadalajara, Av. Rafael Casillas Aceves 1200, Tepatitlán de Morelos, 47600, Jalisco, México.
  • 2 Laboratorio de Materiales, Centro Universitario de Los Altos, Universidad de Guadalajara, Agua y Energía, Tepatitlán de Morelos, Jalisco, México.
  • 3 Instituto de Investigación en Biociencias, Centro Universitario de Los Altos, Universidad de Guadalajara, Av. Rafael Casillas Aceves 1200, Tepatitlán de Morelos, 47600, Jalisco, México. [email protected].
Type
Published Article
Journal
Biological Trace Element Research
Publisher
Springer-Verlag
Publication Date
Feb 01, 2024
Volume
202
Issue
2
Pages
558–568
Identifiers
DOI: 10.1007/s12011-023-03685-1
PMID: 37119340
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Fructose consumption has increased globally and has been linked to obesity, insulin resistance, and diabetes. Selenium nanoparticles (SeNPs) can regulate glucose and lipid concentrations and have immunoregulatory properties. Four study groups (n = 7/group) of eight-week-old male mice (Balb/c) were formed for this investigation. One group received a standard diet (C), another standard diet plus SeNPs (C + SeNPs), a high fructose diet (F), and a group with a high fructose diet plus SeNPs (F + SeNPs). Weight, glucose, triglycerides, and cholesterol were evaluated. In the end, mice were sacrificed, blood samples were obtained to assess cytokine profile, and liver, kidney, and pancreas were removed for histological examination. The study was complemented with an in silico analysis where the CTD, STITCH, ToppGene Suite, ShinyGO 0.76.3 databases, and Cytoscape software were implemented. The results of in vivo analysis showed that SeNPs regulated biochemical parameters and showed anti-inflammatory effects by decreasing the concentrations of TNF-alpha, IL-1beta, and IFN-gamma and increasing IL-10. No damage was observed in the studied organs. In addition, SeNPs regulate oxidative stress, preserve cell organelles, and regulate metabolic pathways to avoid the adverse effects of fructose consumption, according to bioinformatics analysis. In conclusion, SeNPs protect against the undesirable effects of a diet rich in fructose. © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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