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Effect of the addition of nano-sized sodium hexametaphosphate to fluoride toothpastes on tooth demineralization: an in vitro study

Authors
  • Dalpasquale, Giovanna1
  • Delbem, Alberto Carlos Botazzo1
  • Pessan, Juliano Pelim1
  • Nunes, Gabriel Pereira1
  • Gorup, Luiz Fernando2
  • Neto, Francisco Nunes Souza2
  • de Camargo, Emerson Rodrigues2
  • Danelon, Marcelle1
  • 1 São Paulo State University (Unesp), School of Dentistry, Araçatuba, Department of Pediatric Dentistry and Public Health, Rua José Bonifácio 1193, Araçatuba, São Paulo, 16015-050, Brazil , Araçatuba (Brazil)
  • 2 Federal University of São Carlos (UFSCar), LIEC-Department of Chemistry, Rodovia Washington Luís, São Carlos, São Paulo, 13565-905, Brazil , São Carlos (Brazil)
Type
Published Article
Journal
Clinical Oral Investigations
Publisher
Springer-Verlag
Publication Date
Feb 28, 2017
Volume
21
Issue
5
Pages
1821–1827
Identifiers
DOI: 10.1007/s00784-017-2093-3
Source
Springer Nature
Keywords
License
Yellow

Abstract

ObjectiveThis study evaluated the effect of toothpastes containing 1100 ppm F associated with nano-sized sodium hexametaphosphate (HMPnano) on enamel demineralization in vitro using a pH-cycling model.DesignBovine enamel blocks (4 mm × 4 mm, n = 72) selected by initial surface hardness (SHi) were randomly allocated into six groups (n = 12), according to the test toothpastes: without fluoride or HMPnano (Placebo), 550 ppm F (550F), 1100 ppm F (1100F), 1100F plus HMPnano at concentrations of 0.25% (1100F/0.25%HMPnano), 0.5% (1100F/0.5%HMPnano), and 1.0% (1100F/1.0%HMPnano). Blocks were treated 2×/day with slurries of toothpastes and submitted to five pH cycles (demineralizing/remineralizing solutions) at 37 °C. Next, final surface hardness (SHf), integrated loss subsurface hardness (ΔKHN), integrated mineral loss (gHAp × cm−3), and enamel fluoride (F) concentrations were determined. Data were analyzed by ANOVA and Student-Newman-Keuls test (p < 0.001).ResultsToothpaste with 1100F/0.5%HMPnano led to the lowest mineral loss and the highest mineral concentration among all groups, which were 26% (SHf) and 21% (ΔKHN) lower and ~58% higher (gHAp × cm−3) when compared to 1100F (p < 0.001). Similar values of enamel F were observed for all fluoridated toothpastes (p > 0.001).ConclusionThe addition of 0.5%HMPnano to a 1100 F toothpaste significantly enhances its effects against enamel demineralization when compared to its counterpart without HMPnano in vitro.Clinical significanceToothpaste containing 1100 ppm F associated with HMPnano has a higher potential to reduce the demineralization compared to 1100 ppm F. This toothpaste could be a viable alternative to patients at high risk of caries.

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