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Effect of acetylcholine on glycogen phosphorylase activity and cyclic nucleotide content in isolated perfused rat hearts.

Authors
  • Gardner, R M
  • Allen, D O
Type
Published Article
Journal
Journal of cyclic nucleotide research
Publication Date
Jan 01, 1976
Volume
2
Issue
3
Pages
171–178
Identifiers
PMID: 180066
Source
Medline
License
Unknown

Abstract

Acetylcholine (1muM) increased cyclid GMP content in paced perfused rat hearts within 15 sec., with peak content occurring at 1 min. No effect of acetylcholine on cyclic AMP content, phosphorylase activity or glycogen synthase was observed. Epinephrine (1muM) infusion increased both cyclic AMP content and phosphorylase, but did not alter cyclic GMP content or glycogen synthase activity. When acetylcholine was infused during the second min. of a 2 min. infusion of epinephrine, the cholinergic agent increased cyclic GMP and reduced the stimulated phosphorylase activity and elevated cyclic AMP.

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