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The effect of 6-aminodopamine on electrical self-stimulation in rats.

Authors
  • Monasmith, B
  • Plotsky, P
  • Blank, C L
  • Adams, R N
Type
Published Article
Journal
Pharmacology Biochemistry and Behavior
Publisher
Elsevier
Publication Date
Jul 01, 1976
Volume
5
Issue
1
Pages
19–21
Identifiers
PMID: 996040
Source
Medline
License
Unknown

Abstract

The compound 6-aminodopamine is a powerful CNS catecholaminergic neurotoxin. Small dosages of 6-aminodopamine injected intraventricularly markedly depress electrical self-stimulation rates in rats. This 6-aminodopamine treatment produced whole brain lowering of norepinephrine to ca. 50% of normal while the dopamine content was unchanged. The possible use of 6-aminodopamine treatment to elucidate the relative roles of norepinephrine and dopamine pathways is discussed.

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