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Effect of 5-HT(2A) receptor antagonists on blood flow in the carotid vessels upon elevation of serotonin level.

Authors
  • Yakovlev, D S
  • Spasov, A A
  • Mal'tsev, D V
  • Anisimova, V A
Type
Published Article
Journal
Bulletin of experimental biology and medicine
Publication Date
Jul 01, 2014
Volume
157
Issue
3
Pages
350–352
Identifiers
DOI: 10.1007/s10517-014-2563-4
PMID: 25070162
Source
Medline
License
Unknown

Abstract

We studied the ability of predominantly 5-HT2A receptor antagonists to prevent a serotonin-induced change of blood flow in the carotid vessels of rats with experimental serotonin-induced spasm. Ritanserin, ketanserin, and 5-HT2A receptor antagonist RU-476 reduced the effect of serotonin on the blood fl ow velocity in the internal carotid artery by 2.3, 1.7, and 2.6 times, respectively.

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