Effect of 5-HT(2A) receptor antagonists on blood flow in the carotid vessels upon elevation of serotonin level.
- Authors
- Type
- Published Article
- Journal
- Bulletin of experimental biology and medicine
- Publication Date
- Jul 01, 2014
- Volume
- 157
- Issue
- 3
- Pages
- 350–352
- Identifiers
- DOI: 10.1007/s10517-014-2563-4
- PMID: 25070162
- Source
- Medline
- License
- Unknown
Abstract
We studied the ability of predominantly 5-HT2A receptor antagonists to prevent a serotonin-induced change of blood flow in the carotid vessels of rats with experimental serotonin-induced spasm. Ritanserin, ketanserin, and 5-HT2A receptor antagonist RU-476 reduced the effect of serotonin on the blood fl ow velocity in the internal carotid artery by 2.3, 1.7, and 2.6 times, respectively.
