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Effect of 308 nm excimer laser irradiation on retinal pigment epithelium cell viability in vitro.

Authors
  • Krohne, T U
  • Hunt, S
  • Holz, F G
Type
Published Article
Journal
British Journal of Ophthalmology
Publisher
BMJ
Publication Date
Jan 01, 2009
Volume
93
Issue
1
Pages
91–95
Identifiers
DOI: 10.1136/bjo.2008.145102
PMID: 18952645
Source
Medline
License
Unknown

Abstract

Cultured human RPE cells are susceptible to apoptotic cell death induced by 308 nm excimer laser irradiation. Absorption by choroid/Bruch membrane tissue can largely prevent the cytotoxic effect. In clinical application, the residual adverse effect of laser ablation on graft RPE cell viability needs to be outweighed by potential advantageous effects on graft survival and functionality to allow for a sensible application of excimer ablation in RPE translocation surgery.

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