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Seroprevalence of Hepatitis B and C in HIV Seropositive and Chronic Renal Failure Patients in North India

Authors
Journal
Journal of Laboratory Physicians
0974-2727
Publisher
Medknow Publications
Publication Date
Volume
3
Issue
2
Identifiers
DOI: 10.4103/0974-2727.86855
Keywords
  • Letters To Editor
Disciplines
  • Medicine

Abstract

Sir, The significant burden of human immunodeficiency virus/hepatitis B virus (HIV/HBV) or HIV/hepatitis C virus (HIV/HCV) coinfection is increasingly being recognized worldwide and in particular within the Asia-Pacific region. Coinfected individuals are at risk from accelerated liver disease and consequently cirrhosis, liver failure, and hepatocellular carcinoma. Also these individuals have altered immunological responses to highly active antiretroviral therapy (HAART) and are at increased risk of drug-related hepatotoxicity. HBV and HCV infections pose increased risk in renal dialysis unit due to the frequent use of blood, blood products and multiple invasive medical procedures. Thus, there is a need to screen for these viruses in HIV seropositive and chronic renal failure (CRF) patients. The present study describes the results of screening for HBV and HCV in 391 HIV individuals and 201 CRF patients. As a control group, 511 antenatal women were also screened for these viruses. The results are shown in Figure 1. Figure 1 Bar diagram showing mean age ± SD and percentage positivity of HBsAg and anti-HCV in the HIV, CRF, and control group. Anti HCV antibody in HIV infected vs healthy controls (P < 0.0001) £. In CRF, vs healthy controls, HBsAg (P < 0.0001)#, anti-HCV (P < 0.005)$, respectively. In HIV vs. CRF seroprevalence of HBsAg was significantly higher in CRF (P = 0.0123)*. The male: female ratio in HIV and CRF group was 1.7:1 and 3:1, respectively. In the HIV group, 8 (2.04%) were HBsAg and 24 (6.1%) were anti-HCV positive. In CRF group, 12 (5.97%) were HBsAg and 7 (3.48%) were anti-HCV positive. Significantly higher seroprevalence of anti-HCV was seen in both the HIV and CRF group as compared to control group. Similarly HBsAg positivity was higher in both the groups as compared to control group. However, statistically significant difference was seen only in CRF group. As the values are categorical variables therefore level of significance was tested us

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