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Inhibition of interferon-α/β induction by crystalline cadmium sulfide

Authors
Journal
Environmental Research
0013-9351
Publisher
Elsevier
Publication Date
Volume
42
Issue
1
Identifiers
DOI: 10.1016/s0013-9351(87)80021-x
Disciplines
  • Medicine

Abstract

The induction of interferon-α/β by Newcastle disease virus in L-929 cells was inhibited by pretreatment of the cell cultures with the crystalline form of cadmium sulfide. As little as 10 μg/ml of crystalline cadmium sulfide was sufficient to inhibit the induction of interferon. Cell viability was not affected by this treatment as measured by trypan blue dye-exclusion viability staining. Between 6 and 24 hr of preincubation with crystalline cadmium sulfide was required for significant inhibition of interferon induction.

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