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Inhibition of human natural killer cell activity by prostaglandin D2

Authors
Journal
Immunology Letters
0165-2478
Publisher
Elsevier
Publication Date
Volume
7
Issue
3
Identifiers
DOI: 10.1016/0165-2478(83)90061-5
Keywords
  • Nk Cells
  • Immunoregulation
  • Prostaglandin D2
  • Cyclic Amp

Abstract

Abstract We have studied the effect of prostaglandin (PG) D 2 on human natural killer (NK) cell activity using 51Cr-labelled K562 target cells. PGD 2 caused a dose dependant inhibition of NK cell activity, producing maximal, non-toxic inhibition at a concentration of 1 × 10 −6 M. This inhibition was not due to interference with effector target cell binding (E:TCB) and was seen using Percoll-enriched NK cells. A time dependent inhibition of NK cell activity was seen when dibutyryl cyclic AMP (DiBcAMP) and PGD 2 were added in parallel to the NK cell assay suggesting that PGD 2 directly inhibits NK cell activity via the adenylate cyclase system which modulates the killing process.

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