In this chapter the access to knowledge (A2K) movement is based on definitions coined by theorists Benkler (2006), Balkin (2010) and Shaver (2007), who advance the concept of human development and equal access to knowl- edge as distributive justice. This chapter focuses on the role of Latin American countries in the WIPO development agenda and the role of library associations against excessive intellectual property regulations which impose barriers to access and ultimately the creation of new knowledge. The concepts of A2K to Open Access (OA), showing how OA can restore knowledge as a public good on a global scale. The chapter also provides an account of the growth of global OA, portrays the Latin American situation and takes into account OA indicators from Ar- gentina, Chile and Brazil. It also reports on international and regional projects, describing several collaborative projects developed in the region. The results of a survey to members of the LLAAR1 discussion list are presented. Finally, the chapter arrives at conclusions that integrate the concepts of A2K, OA, col- laborative work, and development and growth of Open Access in the region.