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Evidence for protein phosphorylation as a regulatory mechanism for hepatic microsomal glucose 6 phosphatase

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
103
Issue
3
Identifiers
DOI: 10.1016/0006-291x(81)90912-8
Disciplines
  • Biology

Abstract

Abstract Incubation of microsomal vesicles with ATP and protein kinase results in a fivefold increased glucose-6-phosphatase activity. Evidence is presented that this effect is mediated via a moiety of the outer membrane surface. Evidence is also presented for the presence of an endogenous, peripheral membrane protein also capable of activating glucose-6-phosphatase in an ATP dependent reaction. It is suggested that the glucose-6-phosphate transmembrane carrier system may be the target of phosphorylation.

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