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Preclinical characterization of the myxobacterial compound pretubulysin as novel vascular disrupting agent

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Ludwig-Maximilians-Universität München
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  • Fakultät Für Chemie Und Pharmazie

Abstract

Preclinical characterization of the myxobacterial compound pretubulysin as novel vascular disrupting agent Dissertation zur Erlangung des Doktorgrades der Fakultät für Chemie und Pharmazie der Ludwig-Maximilians-Universität München Preclinical characterization of the myxobacterial compound pretubulysin as novel vascular disrupting agent Verena Karoline Kretzschmann aus Stuttgart 2013 Erklärung Diese Dissertation wurde im Sinne von § 7 der Promotionsordnung vom 28. November 2011 von Frau Prof. Dr. Angelika M. Vollmar betreut. Eidesstattliche Versicherung Diese Dissertation wurde eigenständig und ohne unerlaubte Hilfe erarbeitet. München, den 07. November 2013 Verena Karoline Kretzschmann Dissertation eingereicht am: 07.11.2013 1. Gutachter: Prof. Dr. Angelika M. Vollmar 2. Gutachter: Prof. Dr. Robert Fürst Mündliche Prüfung am: 12.12.2013 to my family CONTENTS CONTENTS II 1 INTRODUCTION ........................................................................................... 1 1.1 Background and aim of the study ....................................................................... 2 1.2 Natural compounds .............................................................................................. 4 1.2.1 Importance of natural compounds ....................................................................... 4 1.2.2 Myxobacteria as producers of natural compounds .............................................. 4 1.2.3 The myxobacterial compound pretubulysin ......................................................... 5 1.3 The microtubule system ...................................................................................... 5 1.3.1 Structure of microtubules ...................................................

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